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KMID : 0613820150250050523
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Journal of Life Science
2015 Volume.25 No. 5 p.523 ~ p.532
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Therapeutic Effect of Hydrocolloid Membrane Containing Liriope platyphylla Extracts on the Burn Wounds of SD Rats
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Lee Eun-Hae
Go Jun
Kim Ji-Eun
Koh Eun-Kyoung
Song Sung-Hwa
Sung Ji-Eun
Park Chan-Kyu
Lee Hyun-Ah
Hwang Dae-Youn
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Abstract
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A variety of previous pharmacological studies have suggested Liriope platyphylla (L. platyphylla) may exert beneficial biological effects on inflammation, diabetes, neurodegenerative disorder, obesity, constipation, and atopic dermatitis. In addition, hydrocolloid membranes (HCMs) have attracted attention in dermatological care, including in the treatment of scleroderma skin ulcers, cutaneous ulcers, permanent tympanic membrane perforations, pressure sores, and decubitus ulcers in the elderly. To investigate the therapeutic effects of HCM containing an aqueous extract of L. platyphylla (HCM-LP) on second-degree burn wounds, their physico-chemical properties were analyzed and the therapeutic effects were observed in SD rats after treatment with HCM-LP for 14 days. Significant declines in tensile strength (38.4%) and absorptiveness (46.3%), as well as an increase in surface roughness (38.1%) were detected in HCM-LP compared with that of HCM. In SD rats with burned skin, the wound diameter was shorter in the HCM-LP treated group than in the GZ group on post-surgical day 14, while the significant improvements in scar tissue reduction, epithelium regeneration, angiogenesis, and extracellular matrix deposition were observed in the HCM-LP-treated group during all experimental periods. Overall, these results suggest HCM-LP may accelerate the process of healing the burn injury skin of SD rats through the regulation of angiogenesis and connective tissue formation.
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KEYWORD
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Angiogenesis, hydrocolloid membrane, Liriope platyphylla, physico-chemical properties, surgical wound
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